ELIBIO® Software

DIGITAL LIVER BIOPSY

SOQUT-IMAGING PROVIDES AN MRI IMAGE ANALYSIS SOFTWARE THAT DELIVERS A “DIGITAL BIOPSY” OF THE LIVER. ELIBIO® IS A NON-INVASIVE DIAGNOSTIC TEST ENABLING THE EARLY DIAGNOSIS OF MASH.

ELiBio® is a Saas software that automatically extracts key quantitative markers from dedicated MRI acquisition.

Raw images from MRI scans are converted into parametric maps in which each pixel no longer corresponds to a gray scale value but to a quantitative parameter, a measurement of a tissue component.

Our patented technology uses biochemical shift and physical measurements derived from MRI (type and quantity of liver fat, iron content and magnetic susceptibility properties). These measurements are the key components related to the evaluation of MAFLD-MASH diseases, namely:

  • Fat content (Steatosis) : PDFF extraction from MRI makes it possible to quantify the presence of fat in the liver.
  • Iron content:  R2* extraction from MRI makes it possible to quantify the presence of iron in the liver.
  • Presence of fibrosis: Measuring magnetic susceptibility through post-processing allows for the evaluation of macro-molecules’ presence in the extracellular matrix (including collagen) that indicates the presence of fibrosis and its severity.

ELiBio solution is compatible with almost all MRI brands, models and magnetic fields available on the market and can be added anytime to MRI scanners already in use in Hospitals.

HIGH DIAGNOSTIC PERFORMANCE

Cohort of 32 patients

Completed study

Diagnostic performance: 0.91

(ROC AUC 95%CI: [0.79-1.0])

RESULTS

ELiBio® analysis report is automatically generated. It provides with key information to diagnose MASH presence and severity with:

    • Steatosis score (intrahepatic fat presence),
    • Iron score (intrahepatic iron presence)
    • Fibrosis (using our patented magnetic susceptibility technology).

Results are provided as average values for the whole liver as well as 3D distributions.

SoQut-Imaging EliBio report

ELiBio ANALYSIS STEPS

01

The MRI imaging procedure includes an optimized and dedicated MRI sequence. This breath-holding sequence lasts less than 20 seconds.

02

Once these images have been recovered form PACS, they are automatically prepared (Propriatory file formatting) for ELiBio analysis.

03

ELiBio core process uses patented technologies to compute quantitative biomarkers related to liver health. ELiBio generates 3D parametric mapping of these biomarkers and subsequently an analysis report.

04

The quantitative information produced allows the practitioner to:

  • Make a diagnosis of the patient’s liver condition (MASH/non-MASH);
  • Monitor the progression of the disease and the effectiveness of treatment over time
  • Provide information on the adipose tissue composition

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